Luke N Sharp

This study shows that polygenic risk scores for diabetes traits are associated with higher HbA1c and increased diabetes diagnosis risk in GCK-MODY carriers, highlighting the interaction between monogenic and polygenic factors.

The paper shows that common genetic variants influence disease risk and severity in monogenic diabetes, modifying clinical outcomes in individuals with pathogenic variants.

The paper identifies rare genetic variants associated with birth weight, highlighting genes involved in adipose tissue regulation, placental function, and insulin-like growth factor signaling.