Author

Jacques Murray Leech

University of ExeterORCID 0000-0001-6990-5826Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Andrew Tym HattersleyiD· 2 shared Ankit M ArniiD· 2 shared Kashyap Amratlal PateliD· 2 shared Kevin ColcloughiD· 2 shared Luke N SharpiD· 2 shared Michael N. WeedoniD· 2 shared V. Kartik ChundruiD· 2 shared Robin N. BeaumontiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Andrew Tym HattersleyORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicineDiabetologiaPeer-reviewedMar 18, 2026

Polygenic Background Contributes to GCK-MODY Clinical Presentation and Glycaemic Variability

Jacques Murray Leech, Ankit M Arni, V. Kartik Chundru…·Kashyap Amratlal Patel

This study shows that polygenic risk scores for diabetes traits are associated with higher HbA1c and increased diabetes diagnosis risk in GCK-MODY carriers, highlighting the interaction between monogenic and polygenic factors.

3 citationstop 2%

humanstatistical model

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Genetic & Genomic MedicineNature MetabolismPeer-reviewedSep 9, 2025

Common Genetic Variants Modify Disease Risk and Clinical Presentation in Monogenic Diabetes

Jacques Murray Leech, Robin N. Beaumont, Ankit M Arni…·Kashyap Amratlal Patel

The paper shows that common genetic variants influence disease risk and severity in monogenic diabetes, modifying clinical outcomes in individuals with pathogenic variants.

26 citationstop 1%

humanGWAS summary statistics

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