Weishan Li

Characterizing intra- and inter-tumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics

This study uses single-cell and spatial transcriptomics to analyze intra- and inter-tumor heterogeneity in ovarian HGSC subtypes, identifying spatial patterns and cell-cell communication differences.

Missing cell types in single-cell references impact deconvolution of bulk data but are detectable

The paper examines how missing cell types in single-cell references affect deconvolution of bulk data and shows that missing cell-type profiles can be detected using non-negative matrix factorization.