Laurie Grieshober

This study shows HGSC transcriptomic subtypes are driven by tumor cellular composition rather than intrinsic biology, with high predictive accuracy using deconvolution methods.

The paper deconvolves adipocyte proportions from bulk RNA-seq data of HGSOC tumors and finds higher adipocyte content is associated with worse survival.

This study uses single-cell and spatial transcriptomics to analyze intra- and inter-tumor heterogeneity in ovarian HGSC subtypes, identifying spatial patterns and cell-cell communication differences.

The paper examines how missing cell types in single-cell references affect deconvolution of bulk data and shows that missing cell-type profiles can be detected using non-negative matrix factorization.