BiochemistrybioRxivPreprint
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De novo Design of All-atom Biomolecular Interactions with RFdiffusion3
Jasper Butcher, Rohith Krishna, Raktim Mitra…·David A. Baker
An all-atom diffusion model using a 14-atom residue representation and sparse U-Net architecture accelerates biomolecular design 10-fold, enabling experimentally validated DNA-binding proteins and multi-turnover cysteine hydrolases.
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