Author

Mukundh Murthy

Broad InstituteORCID 0009-0001-7559-2990Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Ajay NadigiD· 1 shared Angela N. PogsoniD· 1 shared Elise RobinsoniD· 1 shared Jonathan S. WeissmaniD· 1 shared Joseph M. ReplogleiD· 1 shared Luke Jen O’ConnoriD· 1 shared Steven A. McCarrolliD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Ajay NadigORCID

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1 paper

Recent·Most cited

GenomicsNature GeneticsPeer-reviewedApr 21, 2025

Transcriptome-wide characterization of genetic perturbations

Ajay Nadig, Joseph M. Replogle, Angela N. Pogson…·Luke Jen O’Connor

The paper introduces TRADE, a statistical framework to detect transcriptome-wide differential expression effects from noisy Perturb-seq data, showing that many true effects are not statistically significant but detectable in aggregate.

70 citationstop 1%

humanCRISPR screen

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