Angela N. Pogson

This study identifies brain macrophages in the African turquoise killifish that engulf brain extracellular material, showing age-related decline in engulfment capacity.

This study identifies CUL3-BTBD9 as an E3 ubiquitin ligase essential for myogenesis by ubiquitylating CAV1 and regulating insulin signaling in myoblasts.

The paper introduces TRADE, a statistical framework to detect transcriptome-wide differential expression effects from noisy Perturb-seq data, showing that many true effects are not statistically significant but detectable in aggregate.

The paper shows how DNA motifs guide transcription factor cooperativity in embryonic face and limb mesenchyme, shaping cell identity and morphology.

This paper develops compact CRISPRi sgRNA libraries and optimal effectors to improve knockdown consistency and efficiency in mammalian cells.

The paper performs genome-scale Perturb-seq to map genotype-phenotype relationships, uncovering new gene functions and stress-specific mitochondrial regulation.

The paper introduces dynamo, a framework for estimating RNA velocities and predicting cell fates using single-cell RNA-seq data, applied to various biological processes.