Genetic background shapes AI-predicted variant effects
Brian M. Schilder, Zhihan Liu, John J. Desmarais, David Laub, Fahimeh Rahimi, Palash Sethi, Lucas A. Pereira, Mengyi Sun, Justin B. Kinney, David M. McCandlish, Juannan Zhou, Peter K. Koo
This study introduces pVEP, a framework showing how genetic background affects AI predictions of variant effects, revealing variant effects vary across haplotypes.
bioRxiv · Apr 7, 2026 · PreprintGenomics