BioinformaticsbioRxivPreprint
Slide-level batch structure limits histology-guided supervision of transcriptomic foundation models
Ulysse McConnell, Kalin Nonchev, Viktor Hendrik Koelzer, Gunnar Rätsch
This paper investigates whether histology can improve transcriptomic foundation models by providing cross-modal supervision, but finds limited benefits due to slide-specific structure in gene-expression embeddings.
DOI 10.64898/2026.09.30.755585