Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 critical for mechanotransduction
Xiaoping Liang, Roshan Pathak, Xufeng Qiu, Lucas B. Dillard, Edward C. Twomey, Ulrich Müller
This study determines the cryo-EM structure of PCDH15, revealing its right-handed double-helix dimer architecture essential for mechanotransduction.
bioRxiv · Mar 4, 2026 · PreprintNeuroscience