Min-frame transformation enables more sensitive viral genome alignment
Ryan Doughty, Ankhi Banerjee, Bryce Kille, Tandy Warnow, Todd J. Treangen
The paper introduces Min-Frame Transformation (MFT) to improve viral genome alignment by enhancing MUM-based seeding, resulting in longer and more contiguous matches with better alignment coverage and SNP recall.
bioRxiv · May 22, 2026 · PreprintBioinformatics