Systems BiologyMathematical Modelling of Natural PhenomenaPeer-reviewed
Conditional Success of Adaptive Therapy: The Role of Treatment-Holiday Thresholds and Non-Existence of Optimal Strategies Revealed by Mathematical Modelling and Optimal Control
Lanfei Sun, Haifeng Zhang, Kai Kang…·Changjing Zhuge
This paper uses mathematical modeling to show adaptive therapy's success depends on treatment thresholds and competitive interactions, with no optimal strategy due to impractical infinite treatment holidays.
DOI 10.1051/mmnp/2026010