Kappa opioid receptors in excitatory spinal neurons gate acute pain: evidence from mouse and human
Nicole A Kooij, Brandon M. Wills, Laney Waydick, Louis G. Fanien, Allison P. Manalo, Tayler D. Sheahan
This study shows that KOR-expressing spinal neurons inhibit acute pain by reducing pain-promoting neuropeptide release in both mouse and human.
bioRxiv · Jul 6, 2026 · PreprintNeuroscience