Modulating Innate Immune Responses to Curli Fibers Through Protein Engineering
Shanna Lillian Bonanno, Rutvi Sheta, Teena Ramu, Shriya Verenkar, Darren Kim, Eva Bessette, Petit Pierre, Neel S Joshi
This paper engineers E. coli curli fibers to inhibit TLR2 activation, demonstrating that direct receptor antagonism is more effective than steric shielding for immune modulation.
Infection and Immunity · Sep 21, 2026Peer-reviewedSynthetic Biology