Sequence-encoded conformational biases shape self-assembly modes of intrinsically disordered proteins
Ryoga Kobayashi, Norio Yoshida, Yohei Miyanoiri, Hideki Nakamura, Miu Ekari, Emi Sakamoto, Misato Tsutsumi, Kayo Imamura, Takashi S Kodama, Hidehito Tochio, Naotaka Sekiyama
This study shows that sequence-encoded conformational biases in intrinsically disordered proteins influence their self-assembly modes, affecting condensate properties and amyloid fibril formation.
bioRxiv · Oct 27, 2025 · PreprintBiophysics