Single JAK2-V617F hematopoietic stem cells can initiate MPN in transplantations into non-conditioned recipient mice
Quentin Kimmerlin, Morgane Hilpert, Nils Hansen, Alexandre Guy, Marc Usart, Jan Stetka, Patryk Sobieralski, Tiago Almeida Fonseca, Hui Hao-Shen, Radek C. Skoda
This study shows that single JAK2-V617F mutant HSCs can initiate MPN in non-irradiated mice, demonstrating their competitive advantage over normal HSCs and highlighting species-specific immune recognition differences.
bioRxiv · Jun 8, 2025 · PreprintCancer Biology