CroCoDeEL: accurate control-free detection of cross-sample contamination in metagenomic data
Lindsay Goulet, Florian Plaza Oñate, Alexandre Famechon, Benoît Quinquis, Eugeni Belda, Edi Prifti, Emmanuelle Le Chatelier, Guillaume Gautreau
CroCoDeEL detects and quantifies cross-sample contamination in metagenomic data without negative controls or prior knowledge, showing high accuracy even at low contamination rates.
Nature Communications · May 9, 2026Peer-reviewedBioinformatics