GenomicsDigestive Diseases and SciencesPeer-reviewed
The ZIP8 A391T Crohn's disease-linked risk variant induces colonic metal ion dyshomeostasis, microbiome compositional shifts, and inflammation
Julianne Ching Yang, Matthew Y. Zhao, Diana A. Chernikova…·Jonathan P. Jacobs
This study shows that the SLC39A8 A391T variant reduces luminal trace metals and alters microbiome composition in mice, leading to spontaneous colonic inflammation.
6 citations