Jonathan P. Jacobs

Akkermansia expansion reduces short-chain fatty acid-producing Firmicutes in human-flora uveitis mice, raising Th1 responses and disease; a Verrucomicrobia/Firmicutes ratio is elevated in uveitis, MS and Crohn's patients.

The paper evaluates lysis and extraction methods using metagenomic reference materials to identify optimal techniques and highlights biases in compositional metrics due to poor lysis.

This study identifies Prevotella copri as a driver of MASLD progression by promoting hepatic steatosis and fibrosis through lipid accumulation and impaired intestinal tight junctions.

This study shows that TL1A overexpression in Crohn's Disease and mice causes Paneth cell dysfunction and microbiota changes that promote ileal inflammation.

The paper investigates shared and distinct functional pathogenicity of gut microbiomes in inflammatory diseases using germ-free mice colonized with human fecal samples.

This study shows that the SLC39A8 A391T variant reduces luminal trace metals and alters microbiome composition in mice, leading to spontaneous colonic inflammation.

The paper shows that IBD microbiotas alter gut CD4 T-cell balance and drive colitis in mice, with specific T-cell profiles predicting disease status and severity.