Pharmacology & ToxicologybioRxivPreprint
A Physics-Constrained Marcus-Theory Optimization Framework Restores Parameter Identifiability in Deep-Pocket Oncogenic Drug Kinetics: A KRAS G12C and STAT3 Case Study
Cluchagues Abam Louis Martin, Kameni Mfabo Ivan Harold, Francois Eya'ane Meva
The paper develops a physics-constrained framework to improve parameter identifiability in drug kinetics by incorporating dielectric permittivity changes, validated with synthetic and real data.
DOI 10.64898/2026.10.28.762299