Zhaoheng Li

This study uses a knockout village framework to analyze how mutations in diabetes genes alter pancreatic beta cell development, revealing non-canonical cell fate shifts and identifying ISL1 as a key regulator.

DANCE provides a benchmark platform for single-cell analysis with 32 methods across 21 datasets, enabling easy reproduction and development of deep learning models.

The paper introduces a large-scale spatial transcriptomic dataset and a Graph Neural Network-based method for cell type deconvolution in human immuno-oncology.