Somatic mutation inference from single-cell transcriptomics: A survey in the esophagus
Alba Méndez-Alejandre, Darío González-Menéndez, Sara Vidal-Notari, Greta Skrupskelyte, María Rodríguez-Rodríguez, Harikrishnan Ajith, Antonio Sánchez Torralba, Maria Pilar Alcolea, Gabriel Piedrafita
This study evaluates SComatic's ability to detect somatic mutations in normal esophageal tissue using scRNA-seq, highlighting technical challenges and methodological improvements.
bioRxiv · Jul 11, 2026 · PreprintBioinformatics