Maria Pilar Alcolea

This study evaluates SComatic's ability to detect somatic mutations in normal esophageal tissue using scRNA-seq, highlighting technical challenges and methodological improvements.

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

This study shows that PIK3CAH1047R mutation causes clonal expansion in capillary and venous endothelial cells but not in arterial cells, revealing stage-dependent responses and a protective mechanism against arterial damage.