Testcrosses are an efficient strategy for identifying cis regulatory variation: Bayesian analysis of allele specific expression (BASE)
Brecca Miller, Alison M. Morse, J. E. Borgert, Zihao Liu, Kelsey Ariel Sinclair, Gavin Gamble, Fei Zou, Jeremy R. B. Newman, Luis León‐Novelo, Fabio Marroni, Lauren M. McIntyre
The paper introduces BASE, a Bayesian pipeline for analyzing allelic imbalance to identify cis regulatory variation, showing it validates ~75% of predicted differences between non-tester alleles.
G3 Genes Genomes Genetics · Mar 27, 2021Peer-reviewedBioinformatics