Author

Brecca Miller

New York UniversityORCID 0000-0002-0560-5397Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:Bayesian inference· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Achim A WerneriD· 1 shared Alison M. MorseiD· 1 shared Amy K. WangiD· 1 shared Dan Avi LandauiD· 1 shared David B. BeckiD· 1 shared Deborah Rivera· 1 shared Duy T. TraniD· 1 shared Fabio MarroniiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Achim A WernerORCID

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2 papers

Recent·Most cited

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING

Samuel J. Magaziner, Jason C. Collins, Brecca Miller, Patrick Zheng, Amy K. Wang, Jérôme Hadjadj, Juan Carlos Balandrán, Maria Sirenko, Maya English, James Bertlin, Rebecca L. Murray, Peter H. Whitney, Tania J González-Robles, Deborah Rivera, Yan Wang, , David B. Beck

This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.

bioRxiv · May 29, 2026 · PreprintGenetics

Testcrosses are an efficient strategy for identifying cis regulatory variation: Bayesian analysis of allele specific expression (BASE)

Brecca Miller, Alison M. Morse, J. E. Borgert, Zihao Liu, Kelsey Ariel Sinclair, Gavin Gamble, Fei Zou, Jeremy R. B. Newman, Luis León‐Novelo, Fabio Marroni, Lauren M. McIntyre

The paper introduces BASE, a Bayesian pipeline for analyzing allelic imbalance to identify cis regulatory variation, showing it validates ~75% of predicted differences between non-tester alleles.

G3 Genes Genomes Genetics · Mar 27, 2021Peer-reviewedBioinformatics