Promoters constrain evolution of expression levels of essential genes inEscherichia coli
Saburo Tsuru, Naoki Hatanaka, Chikara Furusawa
The paper investigates how promoter variability affects the evolution of essential genes in E. coli, finding that promoters of essential genes show biased mutational variability toward lower activity, constraining future expression level evolution.
Molecular Biology and Evolution · Aug 30, 2024Peer-reviewedEvolutionary Biology