Saburo Tsuru

Low-Dimensional Organization of Metabolic Phenotypes Underlies Recurrent Evolutionary Diversification

The paper shows that metabolic phenotypes in Escherichia coli vary along low-dimensional, recurring modules during natural and experimental evolution.

Repeatability of protein structural evolution following convergent gene fusions

The paper investigates structural convergence in fusion enzymes from different gene fusions, showing similar dimeric structures despite distinct overall architectures and amino acid sequences.

Congruence between noise and plasticity in protein expression

This study measures noise and plasticity in protein expression of essential and nonessential genes in E. coli, finding essential genes have lower noise and plasticity, and nonessential genes show a positive correlation between them.

Laboratory evolution of the bacterial genome structure through insertion sequence activation

This study accelerates bacterial genome evolution by introducing multiple insertion sequences into E. coli, resulting in significant genome rearrangements and size changes.

Genetic properties underlying transcriptional variability across different perturbations

The paper investigates how gene regulatory networks influence transcriptional variability in Escherichia coli under different perturbations and identifies genetic properties that explain gene-to-gene differences in transcriptional variation.

Carbon source diversity shapes bacterial interspecies interactions

The paper investigates how carbon source diversity affects interspecies interactions in bacterial communities, finding that cooperation decreases and competition increases with higher carbon diversity.

Promoters constrain evolution of expression levels of essential genes inEscherichia coli

The paper investigates how promoter variability affects the evolution of essential genes in E. coli, finding that promoters of essential genes show biased mutational variability toward lower activity, constraining future expression level evolution.

Operon formation by insertion sequence IS3 in Escherichia coli

This study demonstrates that insertion sequences can facilitate operon formation by altering gene expression and closing gaps between genes in Escherichia coli.