Nuclear exclusion of menin drives functional MEN1 deficiency in non-MEN1 prolactinomas: mouse models and human biopsies
Milagros Peña‐Zanoni, Álvaro Flores‐Martínez, Dana Bornancini, Alejandra Abeledo-Machado, Victoria Segobia, Susana Beatriz Rulli, Raul Miguel Luque, Graciela Dı́az-Torga
The paper shows that menin exclusion from the nucleus in prolactinomas causes functional MEN1 deficiency, even with normal expression, and suggests nuclear menin restoration as a therapeutic target.
bioRxiv · Aug 24, 2026 · PreprintPhysiology