Cancer BiologybioRxivPreprint
A Critical Re-evaluation of the Somatic Mutation Theory (SMT)Conceptual and Quantitative Limits of the Cell-Centric Paradigm
Finn Ernst Olsen, Christian Liisberg
This paper re-evaluates the Somatic Mutation Theory (SMT) and shows that multi-hit carcinogenesis is implausible within realistic timescales, suggesting a shift to communication breakdown as the root cause of cancer.
DOI 10.1101/2025.10.17.683033