FTO-mediated m6A demethylation of ULK1 mRNA promotes autophagy and activation of hepatic stellate cells in liver fibrosis
Tingjuan Huang, Chunhong Zhang, Junjie Ren, Qizhi Shuai, Xiaonan Li, Xuewei Li, Jun Xie, Jun Xu
This study shows FTO promotes autophagy and HSC activation in liver fibrosis by demethylating ULK1 mRNA, with YTHDC2 inhibiting this process.
bioRxiv · Mar 14, 2024 · PreprintMolecular Biology