Jun Xie

This study creates a spatiotemporal atlas to understand mesenchymal-epithelial stem cell dynamics in human hair follicle aging and androgenetic alopecia, identifying PTN as a key regenerative factor.

The paper introduces CIMA, a multi-omics atlas of human immune cells, identifying regulatory mechanisms and genetic associations across sex, age, and genetic factors.

This study identifies TNF and endothelial IL-1R1 signaling as key drivers of capillary regression and fibrosis in obstructive kidney injury, showing that their combined inhibition preserves peritubular capillaries and reduces renal injury.

This study shows that overexpressing ERG in endothelial cells prevents vascular regression and neuronal damage in OIR models, suggesting ERG as a potential therapeutic target for retinopathies.

The paper uses single-cell multiomics to study gene regulatory programs in mouse embryonic skin, identifying cis-regulatory elements and transcription factors involved in development.

The paper constructs a multimodal brain cell atlas of adult macaques across their lifespan, revealing aging-related molecular changes and identifying aging hotspots and regulatory loci.

This study uses multi-omics data to analyze immune and metabolic changes in mountain climbers during acclimatization and extreme altitude exposure.

This study develops a human induced pluripotent stem cell-derived liver organoid model of alcoholic liver disease to evaluate drug treatments and replicate key pathological features.

This study shows FTO promotes autophagy and HSC activation in liver fibrosis by demethylating ULK1 mRNA, with YTHDC2 inhibiting this process.