BioinformaticsNucleic Acids ResearchPeer-reviewed
GEM: A manifold learning based framework for reconstructing spatial organizations of chromosomes
Guangxiang Zhu, Wenxuan Deng, Hailin Hu…·Jianyang Zeng
GEM reconstructs 3D chromatin structures from Hi-C data using manifold learning and conformational energy, outperforming existing methods and recovering long-range interactions.