Author

Guangxiang Zhu

Tsinghua UniversityORCID 0000-0002-0376-8483Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:dimensionality reduction· 2 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 2 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Jianyang ZengiD· 2 shared Ahmed Abbas· 1 shared Bin ZhouiD· 1 shared Hailin HuiD· 1 shared Jian PengiD· 1 shared Jiangpeikun Song· 1 shared Jing NiuiD· 1 shared Jinglin Yang· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioinformatics

Jianyang ZengORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BioinformaticsNature CommunicationsPeer-reviewedMay 3, 2019

Integrating Hi-C and FISH data for modeling 3D organizations of chromosomes

Ahmed Abbas, Xuan He, Jing Niu…·Jianyang Zeng

This paper introduces GEM-FISH, a method that integrates Hi-C and FISH data to improve 3D chromosome modeling, showing better accuracy in TADs, compartments, and super-enhancer distributions than Hi-C alone.

68 citations

Hi-Cstatistical model

𝕏 PostBluesky

BioinformaticsNucleic Acids ResearchPeer-reviewedJan 25, 2018

GEM: A manifold learning based framework for reconstructing spatial organizations of chromosomes

Guangxiang Zhu, Wenxuan Deng, Hailin Hu…·Jianyang Zeng

GEM reconstructs 3D chromatin structures from Hi-C data using manifold learning and conformational energy, outperforming existing methods and recovering long-range interactions.

51 citations

yeasthuman

𝕏 PostBluesky