NeurosciencebioRxivPreprint
A Load-Induced Energetic Tipping Point Explains Selective Vulnerability of Substantia Nigra Neurons
The paper develops a minimal energetic model to explain why SNc neurons are more vulnerable than VTA neurons in Parkinson's disease, showing that load-induced bistability leads to irreversible collapse under stress.
DOI 10.1101/2025.11.16.688654