Author

Han Zhou

University of WaterlooORCID 0009-0003-7472-3244Unclaimed ORCID profile · follow to get notified of new preprints

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Han Zhou6 papers · Dalian Institute of Chemical Physics

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:multiome· 1 Assay:protein sequence· 1

Frequent Co-Authors

Yang Young LuiD· 2 shared Kai CaoiD· 1 shared Yifan YangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 2 mutual co-author links

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2 shared papersBioinformatics

Yang Young LuORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintApr 29, 2026

Diagnosing protein sequence search in the era of language models

Han Zhou, Yifan Yang, Yang Young Lu

This study evaluates the reliability of protein sequence search using language models and finds that classical alignment methods are more robust than PLM-based approaches.

DOI 10.64898/2026.04.26.720921

protein sequencestatistical model

𝕏 PostBluesky

BioinformaticsBioinformaticsPeer-reviewedJun 1, 2025

Securing diagonal integration of multimodal single-cell data against ambiguous mapping

Han Zhou, Kai Cao, Yang Young Lu

The paper introduces SONATA, a diagnostic method to detect artificial integrations in diagonal multimodal single-cell data integration, showing its effectiveness across simulated and real datasets.

2 citations

multiomestatistical model

𝕏 PostBluesky