Eric V Strobl

Mendelianization concentrates polygenic signals into a single causal locus to improve interpretability of complex disorders.

This paper introduces TWRCI, an algorithm that identifies root causal genes and their causal graph using genetic and bulk RNA-seq data, outperforming existing methods in uncovering disease mechanisms.

This paper identifies root causal genes using Perturb-seq data and transfers the findings to bulk RNA-seq to reveal patient-specific root causes of disease.