Systems BiologyCell Communication and SignalingPeer-reviewed
Intercellular signaling reinforces single-cell level phenotypic transitions and facilitates robust re-equilibrium of heterogeneous cancer cell populations
Daniel Lopez, Darren R. Tyson, Tian Hong
The paper investigates how intercellular signaling influences phenotypic transitions in cancer cells using scRNA-seq data and mathematical models, finding that signaling reinforces heterogeneity and robustness in tumor populations.