Davide Cesare Monti

VESPA-SS detects somatic structural variants from long-read sequencing data without requiring read mapping or a high-quality germline reference, achieving high F1 scores on cancer cell lines.

RecAlign improves recombination-aware sequence-to-graph mapping by using an A* algorithm with haplotype information and a heuristic function, achieving faster and more efficient performance.

The paper introduces RecGraph, a tool that extends sequence-to-graph alignment by incorporating recombinations, and evaluates its performance on bacterial pangenome graphs.