Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo
Shenzhi Chen, Vincent Loubière, Ethan W. Hollingsworth, Murakami Ken, Nikolaus Mandlburger, Sandra H. Jacinto, Atrin Dizehchi, Jacob Matthew Schreiber, Evgeny Z. Kvon, Alexander Stark
The paper designs tissue-specific enhancers for mouse embryos using deep learning models trained on chromatin accessibility data and validated enhancers.
Nature Genetics · Aug 25, 2026Peer-reviewedSynthetic Biology