Vincent Loubière

The paper designs tissue-specific enhancers for mouse embryos using deep learning models trained on chromatin accessibility data and validated enhancers.

The paper systematically identifies effector functions of pathogen ORFs across multiple pathways, revealing new roles for known effectors and uncharacterized proteins.

The paper shows that enhancer cooperativity can compensate for reduced activity over large genomic distances by introducing weak enhancers between strong enhancers and promoters.

The paper investigates enhancer-enhancer cooperativity in Drosophila, finding that housekeeping enhancers are additive while developmental enhancers are synergistic.

ORFtag enables proteome-scale tagging and functional screening in mammalian cells, identifying known and novel regulators of transcription and post-transcriptional processes.

The paper shows that transient loss of Polycomb components in Drosophila induces an irreversible cancer fate through epigenetic reprogramming without driver mutations.

The paper shows that different promoter classes use distinct PIC compositions and mechanisms, leading to focused or dispersed transcription initiation patterns in Drosophila.

The paper investigates how enhancers regulate duplicated genes in Drosophila, showing differential activity and evolutionary conservation between tissue-specific and pleiotropic enhancers.