Author

Jiaqi Han

Peking UniversityORCID 0009-0004-2142-1477Unclaimed ORCID profile · follow to get notified of new preprints

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Jiaqi Han1 paper · Peking university;

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Bioinformatics· 1

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Research Focus:differential expression· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

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Matteo A. PellegriniiD· 1 shared Michael James ThompsoniD· 1 shared

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Matteo A. PellegriniORCID

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BioinformaticsbioRxivPreprintNov 19, 2025

MAGIC: Methylation Analysis with Genomic Inferred Contexts

Jiaqi Han, Michael James Thompson, Matteo A. Pellegrini

MAGIC improves differential methylation analysis in WGBS data by modeling genomic heterogeneity with a beta-binomial mixture model, enhancing sensitivity and reducing false positives.

DOI 10.1101/2025.11.19.689248

whole-genome sequencingstatistical model

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