Loss of KMT2D accelerates hypertrophic chondrocyte differentiation and senescence by increasing mitochondrial ROS production
Sara Tholl Halldorsdottir, Stefán Pétursson, Jill A. Fahrner, Agnes Ulfig, Hans Tomas Bjornsson
This study shows that KMT2D deficiency causes chondrocyte hypertrophy and senescence via increased mitochondrial ROS, leading to skeletal abnormalities in KS1.
bioRxiv · Oct 10, 2026 · PreprintMolecular Biology