Assessing genomic reproducibility of read alignment tools
Pelin Icer Baykal, Mike Simonov, Dhrithi Deshpande, Ful Belin Korukoglu, Jaden Moore, Karishma Chhugani, Cecilia Liu, Varuni Sarwal, Neha Rajkumar, Mohammed Alser, Niko Beerenwinkel, Serghei Mangul
This study evaluates the reproducibility of eight read alignment tools using synthetic replicates, finding significant variability in their performance and impact on downstream variant calling.
bioRxiv · May 8, 2025 · PreprintBioinformatics