Single-Cell Study Designs Are Systematically Underpowered for Small-Effect Genes
Chris Crampton, Salman Fawad, Toby Clark, Hiranyamaya Dash, Bence Kövér, Garry Cotton, Donghoon Lee, Eugene Paul Duff, Leonardo Bottolo, Paul McMahan Matthews, Nathan Skene
This study shows that single-cell experiments often lack power to detect small-effect genes, even with 600 donors, and highlights the impact of sequencing depth and cell counts on results.
bioRxiv · Sep 19, 2026 · PreprintGenomics