Paul McMahan Matthews

Neuronal and glial transcriptional states vary with proximity to tangle-bearing neurons in the human entorhinal cortex

The paper examines how proximity to tangle-bearing neurons affects transcriptional states in human entorhinal cortex cells, finding that nearby neurons and glia show distinct molecular signatures related to disease.

Neurite Complexity and Plasticity Markers Track Synaptic Vesicle Density in the Living Human Brain: A Multimodal PET-MRI-EEG Study

This study links synaptic vesicle density measured by PET with structural and functional neuroplasticity markers using multimodal imaging and EEG in healthy volunteers.

Stage-specific proteomic signatures of synaptopathy in Alzheimers disease

The paper identifies stage-specific synaptic proteomic signatures in Alzheimer's disease and links them to plasma proteins associated with disease progression and cognitive decline.

Single-Cell Study Designs Are Systematically Underpowered for Small-Effect Genes

This study shows that single-cell experiments often lack power to detect small-effect genes, even with 600 donors, and highlights the impact of sequencing depth and cell counts on results.

Glial subcellular specialisation resolved with high resolution spatial transcriptomics

The paper develops a spatial averaging framework to analyze glial subcellular specialization in spatial transcriptomics data from mouse and human brain tissue, revealing differential transcriptomic responses between glial soma and processes in health and disease.

Intrinsic molecular susceptibility underlies selective neuronal vulnerability in the Alzheimer's disease entorhinal cortex

The paper identifies intrinsic molecular features of calbindin-expressing neurons in the entorhinal cortex that contribute to their vulnerability in Alzheimer's disease and suggests potential therapeutic targets.

ABCA7 rs3752231 variant effects on glial responses to amyloid-β and plaque maturation in Alzheimer's disease.

This study examines the effect of the ABCA7 rs3752231 variant on glial responses to amyloid-β and plaque maturation in Alzheimer's disease using post-mortem brain data and single-nucleus RNA sequencing.

Detecting neuroplastic effects induced by ketamine in healthy human subjects: a multimodal approach

This study uses multimodal imaging to show ketamine increases glutamate in the ACC and alters brain network connectivity, suggesting potential long-term neuroplastic effects.

Evaluation of polygenic score for hypertrophic cardiomyopathy in the general population and across clinical settings

This study evaluates polygenic scores for hypertrophic cardiomyopathy (HCM) in the general population and clinical settings, showing increased risk with higher scores and potential for clinical application.

A synaptic-astrocytic proteomic signature associated with synaptopathy in Alzheimer's Disease

This study identifies a synaptic-astrocytic proteomic signature associated with synapse loss in Alzheimer's Disease across different disease stages.

Single-cell Mendelian randomisation identifies cell-type specific genetic effects on human brain disease and behaviour

The paper uses single-cell Mendelian randomisation to identify cell-type specific genetic effects on brain disease and behaviour, revealing 118 genes with causal associations to 16 brain phenotypes.

Single nuclear transcriptional signatures of dysfunctional brain vascular homeostasis in Alzheimer's disease

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

Etifoxine inhibits NLRP3 inflammasome activity in human and murine myeloid cells

This paper shows etifoxine inhibits NLRP3 inflammasome activity in human and murine myeloid cells, with anti-inflammatory effects independent of its known TSPO and GABAA receptor interactions.

Omix: A Multi-Omics Integration Pipeline

Omix integrates and analyzes multi-omics data to generate pseudo-temporal profiles in Alzheimer's Disease using bulk proteomics and transcriptomics datasets.

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics

This paper uses genetic data to investigate the causal relationships between vascular traits like white matter hyperintensity, blood pressure, and stroke with dementia and Alzheimer's disease risk.

Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology

This study uses single-nuclei RNA sequencing to analyze astrocyte and microglial transcriptomes in Alzheimer's disease brains, identifying gene expression differences linked to amyloid-beta and phospho-tau pathology.

scFlow: A Scalable and Reproducible Analysis Pipeline for Single-Cell RNA Sequencing Data

scFlow provides a scalable, reproducible pipeline for analyzing single-cell RNA-seq data, demonstrating its utility with public datasets and extensibility as an open-source tool.

Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy Body diseases

This study uses transcriptomic profiling to identify common and distinct molecular features across Lewy Body diseases, highlighting RNA splicing dysregulation and potential therapeutic targets.

Genomic analysis reveals a functional role for myocardial trabeculae in adults

The paper identifies genetic associations with myocardial trabecular complexity using UK Biobank data and shows a causal link to ventricular function and electrical activity.

The Dementias Platform UK (DPUK) Data Portal

The DPUK Data Portal provides secure access to cohort data for dementia research, supporting multi-modal analyses and collaborations across multiple institutions.

Single nucleus sequencing fails to detect microglial activation

The paper shows that single nucleus RNA-Seq fails to detect microglial activation genes in human brain samples compared to single cell RNA-Seq.

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

This study identifies 46 novel genetic loci associated with alcohol consumption and suggests shared genetic mechanisms with neuropsychiatric disorders using GWAS and functional analyses.

Image Processing and Quality Control for the first 10,000 Brain Imaging Datasets from UK Biobank

The paper describes an automated processing and quality control pipeline for brain imaging data from the first 10,000 UK Biobank participants.

Improving data availability for brain image biobanking in healthy subjects: practice-based suggestions from an international multidisciplinary working group

The paper provides practical recommendations for improving data availability and sharing in brain image biobanking to enhance research and clinical applications.