Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway
Yunfei Mu, Shijia Hu, Xiangyang Liu, Xin Tang, Jiayi Lin, Hongjun Shi
This study shows mechanical forces, specifically shear stress, activate Notch signaling in the endocardium via the mTORC2-PKC pathway, influencing cardiac development.
eLife · Feb 11, 2025Peer-reviewedDevelopmental Biology