Author

Wouter D. Hoff

Oklahoma State UniversityORCID 0009-0004-7523-6576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:bacteria (other)· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Gunnar Hoogerwerf· 2 shared Rosalie L. DohmeniD· 2 shared Aihua XieiD· 1 shared Amber J. Dohmen· 1 shared Anja SpangiD· 1 shared Astrid T. GrootiD· 1 shared Catalina Bradley· 1 shared Clarice Huffman· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

Gunnar Hoogerwerf

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3 papers

Recent·Most cited

Structural divergence in protein evolution of a photoreceptor family undetected by AlphaFold is observed by high sensitivity FT-IR spectroscopy

Rosalie L. Dohmen, Gunnar Hoogerwerf, Aihua Xie, Wouter D. Hoff

The paper uses ancestral sequence reconstruction and FTIR spectroscopy to reveal structural divergence in PYP proteins undetected by AlphaFold.

bioRxiv · Aug 6, 2026 · PreprintBiophysics

Functional insights into the photoactive yellow protein family from homologs, multidomain proteins and inferred pyp operons

Rosalie L. Dohmen, Gunnar Hoogerwerf, Amber J. Dohmen, Madison L. Neal, Catalina Bradley, Clarice Huffman, Sarah M. Teeman, Saylor F. Hampton, Scout Powell, Zariah Gunn, Wouter D. Hoff

The paper identifies 984 PYP homologs and uses bioinformatics to find candidate proteins involved in PYP signal transduction, including histidine kinase and GGDEF/EAL proteins.

Journal of Bacteriology · Dec 10, 2025Peer-reviewedMicrobiology

On distinguishing between canonical tRNA genes and tRNA gene fragments in prokaryotes

Peter T. S. van der Gulik, Martijn Egas, Ken Kraaijeveld, Nina Dombrowski, Astrid T. Groot, Anja Spang, Wouter D. Hoff, Jenna Gallie

The paper identifies mis-categorization of non-canonical tRNA genes as canonical in GtRNAdb and proposes methods to improve tRNA gene annotation in prokaryotes.

RNA Biology · Feb 2, 2023Peer-reviewedGenomics