Author

Zhihan Guo

BGI ResearchORCID 0009-0004-7638-6779Unclaimed ORCID profile · follow to get notified of new preprints

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Zhihan Guo1 paper · Chinese Academy of Sciences

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Hua QiniD· 2 shared Luni Hu· 2 shared Shuangsang FangiD· 2 shared Tianyi XiaiD· 2 shared Yong ZhangiD· 2 shared Ziqing DengiD· 2 shared Hansheng ZhaoiD· 1 shared Lei CaoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBioinformatics

Hua QinORCID

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2 papers

Recent·Most cited

RegFormer: A Single-Cell Foundation Model Powered by Gene Regulatory Hierarchies

Luni Hu, Hua Qin, Yong Zhang, Yi Lu, Ping Qiu, Zhihan Guo, Lei Cao, Wenjian Jiang, Qianqian Chen, Qianqian Chen, Yanbang Shang, Tianyi Xia, Ziqing Deng, Xun Xu, Hansheng Zhao, , Yuxiang Li

RegFormer improves single-cell RNA sequencing analysis by integrating gene regulatory networks with Mamba-based modeling, outperforming existing models in clustering, integration, and annotation.

Nature Communications · May 5, 2026Peer-reviewedBioinformatics

DynPerturb:Dynamic Perturbation Modeling for Spatiotemporal Single-Cell Systems

Hua Qin, Yilin Zhang, Zhihan Guo, Luni Hu, Qingsong Li, Lei Cao, Tianyi Xia, Ziqing Deng, Yong Zhang, Yuxiang Ping Li, Shuangsang Fang

DynPerturb models spatiotemporal perturbation dynamics in single-cell and spatial transcriptomics, outperforming existing methods in regulatory link prediction and uncovering dynamic regulatory rewiring in biological systems.

bioRxiv · Sep 15, 2025 · PreprintBioinformatics