RegFormer: A Single-Cell Foundation Model Powered by Gene Regulatory Hierarchies
Luni Hu, Hua Qin, Yong Zhang, Yi Lu, Ping Qiu, Zhihan Guo, Lei Cao, Wenjian Jiang, Qianqian Chen, Qianqian Chen, Yanbang Shang, Tianyi Xia, Ziqing Deng, Xun Xu, Hansheng Zhao, , Yuxiang Li
RegFormer improves single-cell RNA sequencing analysis by integrating gene regulatory networks with Mamba-based modeling, outperforming existing models in clustering, integration, and annotation.
Nature Communications · May 5, 2026Peer-reviewedBioinformatics