Improving diffusion-based protein backbone generation with global-geometry-aware latent encoding
Yuyang Zhang, Yuhang Liu, Zinnia Ma, Min Li, Chunfu Xu, Haipeng Gong
This paper introduces TopoDiff, a diffusion-based framework for protein backbone generation that improves global geometry control and fold diversity through a structure encoder and latent sampler.
Nature Machine Intelligence · Jun 18, 2025Peer-reviewedBioengineering